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KMID : 0352719870110020191
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Journal of Ginseng Research
1987 Volume.11 No. 2 p.191 ~ p.202
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Effect of the Saponin Fraction of Korea Ginseng on the Ethanol Metabolism in the Animal Body
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Joo Chung-No
Kwak Hahn-Shik
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Abstract
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Ethanol exerts different effects on hepatic cellular metabolism, depending mainly on the duration of its intake. In the presence of ethanol following an acute load, a number of hepatic functions are inhibited, including lipid oxidation and microsomal drug metabolism.
In its early stages, chronic ethanol consumption produces adaptive metabolic changes in the endoplasmic reticulum which result in incresed metabolism of ethanol and drugs and accelerated lipoprotein production. Prolongation of ethanol intake may result in injurious hepatic lesions such as alcoholic hepatitis and cirrhosis.
A number of such metabolic effects of ethanol are directly linked to the two major_ products of its oxidation; hydrogen and acetaldehyde. The excess hydrogen from ethanol unbalances the liver cell´s chemistry. In the presence of excess hydrogen ions the process is turned in a different direction
In this study, it was attempted to observe the effect of ginseng saponins on alcohol dehydrogenase(ADH), aldehyde dehydrogenase(ALDH) and microsomal ethanol oxidizing system(MEOS) in vivo as well as in vitro. Furthermore, the effect of ginseng saponin on the hydrogen balance in the liver and the hepatic cellular distribution of [1-14C] ethanol, its incorporation into acetaldehyde and lipids was also investigated.
It seemed that ginseng saponin stimulated the above enzymes and other related enzymes in ethanol metabolism, resulting in a rapid removal of acetaldehyde and excess hydrogen from the animal body.
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